Research Interest Statement:
Biomarkers for early prediction of doxorubicin (DOX)-induced cardiotoxicity in breast cancer. The overall goal of this project is to identify biomarkers for prediction of early pre-symptomatic cardiotoxicity of cancer chemotherapy with doxorubicin. Exosomes as biomarkers and therapeutic targets in early breast cancer. This study aims to examine exosomes as non-invasive surrogate markers for prediction of therapeutic response after the early doses of neodjuvant chemotherapy in breast cancer patients. Exosomal miRNA profiling of plasma of patients with early breast cancer treated with neoadjuvant DOX-based chemotherapy is currently under analysis using miRNA-Seq. Role of exosomes in the establishment, development and metastasis of hepatocellular carcinoma. This project aims to characterize exosomal microRNA and protein profiling in hepatocellular carcinoma, and their role in angiogenesis. Exosomal miRNA sequencing is currently ongoing.
NIH/Nat. Inst. of General Medical Sciences – 2P20GM109005
“Center for Studies on Host Response to Cancer Therapy”
08/17/20 – 05/31/25
Todorova VK, Siegel ER, Kaufmann Y, [et al.]. Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model. Translational oncology. 2020 13(2):471-480. PMID: 31918212. PMCID: PMC7031101.
Hsu PC, Kadlubar SA, Siegel ER, [et al., including Todorova VK]. Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer. PloS one. 2020 15(4):e0230248. PMID: 32298288. PMCID: PMC7162481.
Jamshidi-Parsian A, Griffin RJ, Kore RA, [et al., including Todorova VK]. Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma. Experimental cell research. 2018 372(1):16-24. PMID: 30205087.
Yu LR, Cao Z, Makhoul I, [et al., including Todorova VK]. Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Experimental biology and medicine (Maywood, N.J.). 2018 243(3):248-255. PMID: 29224368. PMCID: PMC5813873.
Todorova VK, Makhoul I, Dhakal I, [et al.]. Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. Oncology research. 2017 25(8):1223-1229. PMID: 28256194.
Todorova VK, Makhoul I, Wei J, Klimberg VS. Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients. Annals of clinical and laboratory science. 2017 47(2):115-119. PMID: 28442511.
Makhoul I, Todorova VK, Siegel ER, [et al.]. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PloS one. 2017 12(1):e0168550. PMID: 28045923. PMCID: PMC5207665.
Todorova VK, Makhoul I, Siegel ER, [et al.]. Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. PloS one. 2016 11(8):e0160224. PMID: 27490685. PMCID: PMC4973957.
Rubio I, Suva LJ, Todorova V, [et al.]. Oral glutamine reduces radiation morbidity in breast conservation surgery. JPEN. Journal of parenteral and enteral nutrition. 2013 37(5):623-30. PMID: 23389298.
Todorova VK, Beggs ML, Delongchamp RR, [et al.]. Transcriptome profiling of peripheral blood cells identifies potential biomarkers for doxorubicin cardiotoxicity in a rat model. PloS one. 2012 7(11):e48398. PMID: 23209553. PMCID: PMC3507887.
Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer chemotherapy and pharmacology. 2011 67(2):285-91. PMID: 20383709.
Todorova VK, Kaufmann Y, Klimberg VS. Increased efficacy and reduced cardiotoxicity of metronomic treatment with cyclophosphamide in rat breast cancer. Anticancer research. 2011 31(1):215-20. PMID: 21273601.
Todorova VK, Kaufmann Y, Hennings LJ, Klimberg VS. Glutamine regulation of doxorubicin accumulation in hearts versus tumors in experimental rats. Cancer chemotherapy and pharmacology. 2010 66(2):315-23. PMID: 19898822.
Todorova VK, Klimberg VS, Hennings L, [et al.]. Immunomodulatory effects of radiofrequency ablation in a breast cancer model. Immunological investigations. 2010 39(1):74-92. PMID: 20064086.
Todorova VK, Kaufmann Y, Hennings L, Klimberg VS. Oral glutamine protects against acute doxorubicin-induced cardiotoxicity of tumor-bearing rats. The Journal of nutrition. 2010 140(1):44-8. PMID: 19889810.
Todorova V, Vanderpool D, Blossom S, [et al.]. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition (Burbank, Los Angeles County, Calif.). 2009 25(7-8):812-7. PMID: 19251394.
Kaufmann Y, Todorova VK, Luo S, Klimberg VS. Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model. Nutrition and cancer. 2008 60(4):518-25. PMID: 18584486.
Todorova VK, Kaufmann Y, Luo S, Klimberg VS. Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine. Nutrition and cancer. 2006 54(2):263-73. PMID: 16898871.
Todorova VK, Harms SA, Kaufmann Y, [et al.]. Effect of dietary glutamine on tumor glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats. Breast cancer research and treatment. 2004 88(3):247-56. PMID: 15609127.
Todorova VK, Harms SA, Luo S, [et al.]. Oral glutamine (AES-14) supplementation inhibits PI-3k/Akt signaling in experimental breast cancer. JPEN. Journal of parenteral and enteral nutrition. 2003 27(6):404-10. PMID: 14621121.
Todorova VK, Elbein AD, Kyosseva SV. Increased expression of c-Jun transcription factor in cerebellar vermis of patients with schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 28(8):1506-14. PMID: 12799614.
Johnson AT, Kaufmann YC, Luo S, [et al., including Todorova V]. Effect of glutamine on glutathione, IGF-I, and TGF-beta 1. The Journal of surgical research. 2003 111(2):222-8. PMID: 12850466.
Todorova VK, Stoyanov DI. Partial characterization of serine proteinases secreted by adult Trichinella spiralis. Parasitology research. 2000 86(8):684-7. PMID: 10952270.
Todorova VK. Proteolytic enzymes secreted by larval stage of the parasitic nematode Trichinella spiralis. Folia parasitologica. 2000 47(2):141-5. PMID: 10945739.
Todorova V, Stoyanov A, Nenov D. Reversible chronic renal failure in the elderly. Geriatric nephrology and urology. 1997 7(1):59. PMID: 9422441.
Moore J, Todorova V, Kennedy MW. A cDNA encoding ribosomal protein L3 from the parasitic nematode Toxocara canis. Gene. 1995 165(2):239-42. PMID: 8522183.
Todorova VK, Knox DP, Kennedy MW. Proteinases in the excretory/secretory products (ES) of adult Trichinella spiralis. Parasitology. 1995 111 ( Pt 2):201-8. PMID: 7675535.
Todorova VK, Tankov CV, Dimitrov TV. Trichinella spiralis--characterization of circulating and immune-complex-associated antigens. Parasitology research. 1993 79(1):86-8. PMID: 8469676.
Todorova V, Stratev S. [The complications of the polycystic kidney requiring surgical treatment]. Khirurgiia. 1991 44(1):41-5. PMID: 1942903.
Todorova V, Krustev L, Svilenov D, [et al.]. Antigen-antibody complexes in experimental infection with Trichinella spiralis and their role in the development of kidney lesions. Angewandte Parasitologie. 1990 31(1):35-42. PMID: 2186668.