Intawat Nookaew, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biomedical Informatics

Cancer Research Interest

• Disease Site Focus: Brain, Breast, GI, Head and Neck, Multiple Myeloma, Thoracic/ Lung
• Research Focus Area: Informatics, Detection, Carcinogenesis, Diagnosis/ Prognosis
• Type of Research: Basic

Contact Information

• Email Address: INOOKAEW@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of Allergy & Infectious Diseases – 1R01AI181787
  “Defining KSHV LANA functions in viral pathogenesis and immune evasion”
  Co-Investigator
  7/1/2024 – 5/31/2029
• NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases – 1R01AR082418
  “Antagonism of RANKL signaling by estrogen in osteoclasts”
  Co-Investigator
  3/22/2024 – 2/28/2025
• NIH/Nat. Cancer Institute – 1R21CA285135
  “Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma”
  Co-Investigator
  8/1/2023 – 7/31/2025
• NIH/Nat. Cancer Institute – 2R01CA209882
  “Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma”
  Co-Investigator
  7/1/2023 – 6/30/2028
• NIH/Nat. Cancer Institute – 2R01CA143130
  “Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses-Renewal”
  Co-Investigator
  7/1/2021 – 6/30/2026

Recent Publications

• Kaur J, Adhikari M, Sabol HM, [et al., including Nookaew I]. Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metastasis. Cancer research. 2024. PMID: 39312185.
• Nookaew I, Xiong J, Onal M, [et al.]. Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone. The Journal of biological chemistry. 2024 300(4):107158. PMID: 38479598. PMCID: PMC11007436.
• Azhar G, Verma A, Robeson MS, [et al., including Nookaew I]. Short-Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome. Molecular nutrition & food research. 2024:e2300716. PMID: 38426663.
• Sabol HM, Ashby C, Adhikari M, [et al., including Nookaew I]. A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma. Haematologica. 2024. PMID: 38385272. PMCID: PMC11290536.
• Cheng Y, Sun F, Alapat DV, [et al., including Nookaew I]. High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma. Cell reports. Medicine. 2023 4(10):101214. PMID: 37794587. PMCID: PMC10591052.
• Fu Q, Bustamante-Gomez NC, Reyes-Pardo H, [et al., including Nookaew I]. Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation. JCI insight. 2023 8(18). PMID: 37581932. PMCID: PMC10561722.
• Chuaypen N, Jinato T, Avihingsanon A, [et al., including Nookaew I]. Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection. Scientific reports. 2023 13(1):14413. PMID: 37660163. PMCID: PMC10475021.
• Laster DJ, Akel NS, Hendrixson JA, [et al., including Nookaew I]. CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system. iScience. 2023 26(8):107428. PMID: 37575184. PMCID: PMC10415806.
• Wongsurawat T, Jenjaroenpun P, Anekwiang P, [et al., including Nookaew I]. Exploiting nanopore sequencing for characterization and grading of IDH-mutant gliomas. Brain pathology (Zurich, Switzerland). 2023:e13203. PMID: 37574201. PMCID: PMC10711254.
• Mehdi SJ, Ghatak K, Ling W, [et al., including Nookaew I]. Growth and dormancy control of myeloma cells by mesenchymal stem cells. Leukemia research. 2023 133:107355. PMID: 37499483.
• Warren A, Porter RM, Reyes-Castro O, [et al., including Nookaew I]. The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice. Nature communications. 2023 14(1):3616. PMID: 37330524. PMCID: PMC10276814.
• Marino S, Akel N, Li S, [et al., including Nookaew I]. Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice. Bone research. 2023 11(1):32. PMID: 37311786. PMCID: PMC10264430.
• Marino S, Akel N, Li S, [et al., including Nookaew I]. Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice. Bone research. 2023 11(1):23. PMID: 37147286. PMCID: PMC10163036.
• Marino S, Akel N, Li S, [et al., including Nookaew I]. Reversal of the diabetic bone signature with anabolic therapies in mice. Bone research. 2023 11(1):19. PMID: 37076478. PMCID: PMC10115794.
• Taylor MK, Williams EP, Xue Y, [et al., including Nookaew I]. Dissecting Phenotype from Genotype with Clinical Isolates of SARS-CoV-2 First Wave Variants. Viruses. 2023 15(3). PMID: 36992320. PMCID: PMC10059853.
• Wanichthanarak K, Nookaew I, Pasookhush P, [et al.]. Revisiting chloroplast genomic landscape and annotation towards comparative chloroplast genomes of Rhamnaceae. BMC plant biology. 2023 23(1):59. PMID: 36707785. PMCID: PMC9883906.
• Agoro R, Nookaew I, Noonan ML, [et al.]. Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease. Frontiers in endocrinology. 2023 14:1063083. PMID: 36777346. PMCID: PMC9910177.
• Wanchai V, Jenjaroenpun P, Leangapichart T, [et al., including Nookaew I]. CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences. Briefings in bioinformatics. 2022. PMID: 36198068. PMCID: PMC10144670.
• Li X, Kordsmeier J, Nookaew I, [et al.]. Piezo1 stimulates mitochondrial function via cAMP signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 36(10):e22519. PMID: 36052712. PMCID: PMC10167693.
• Gai D, Chen JR, Stewart JP, [et al., including Nookaew I]. CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation. The Journal of clinical investigation. 2022. PMID: 35881476. PMCID: PMC9479617.
• Joffré E, Xiao X, Correia MSP, [et al., including Nookaew I]. Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors. Microbiology spectrum. 2022:e0175521. PMID: 35876501. PMCID: PMC9431495.
• Kunadirek P, Pinjaroen N, Nookaew I, [et al.]. Transcriptomic Analyses Reveal Long Non-Coding RNA in Peripheral Blood Mononuclear Cells as a Novel Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma. International journal of molecular sciences. 2022 23(14). PMID: 35887228. PMCID: PMC9324406.
• Ponte F, Kim HN, Warren A, [et al., including Nookaew I]. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Scientific reports. 2022 12(1):10257. PMID: 35715555. PMCID: PMC9205908.
• Sabol HM, Amorim T, Ashby C, [et al., including Nookaew I]. Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction. Neoplasia (New York, N.Y.). 2022 28:100785. PMID: 35390742. PMCID: PMC8990177.
• Boysen G, Nookaew I. Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts. Toxics. 2022 10(2). PMID: 35202232. PMCID: PMC8876591.
• Henriksen RA, Jenjaroenpun P, Sjøstrøm IB, [et al., including Nookaew I]. Circular DNA in the human germline and its association with recombination. Molecular cell. 2022 82(1):209-217.e7. PMID: 34951964. PMCID: PMC10707452.
• Wongsurawat T, Jenjaroenpun P, Nookaew I. Direct Sequencing of RNA and RNA Modification Identification Using Nanopore. Methods in molecular biology (Clifton, N.J.). 2022 2477:71-77. PMID: 35524112. PMCID: PMC10619517.
• Wongsurawat T, Jenjaroenpun P, Wanchai V, Nookaew I. Native RNA or cDNA Sequencing for Transcriptomic Analysis: A Case Study on Saccharomyces cerevisiae. Frontiers in bioengineering and biotechnology. 2022 10:842299. PMID: 35497361. PMCID: PMC9039254.
• Wadley T, Moon SH, DeMott MS, [et al., including Nookaew I]. Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences. Frontiers in microbiology. 2022 13:871937. PMID: 35531280. PMCID: PMC9069010.
• Uawisetwathana U, Jamboonsri W, Bamrungthai J, [et al., including Nookaew I]. Metabolite profiles of brown planthopper-susceptible and resistant rice (Oryza sativa) varieties associated with infestation and mechanical stimuli. Phytochemistry. 2021 194:113044. PMID: 34864385.
• Alkam D, Wongsurawat T, Nookaew I, [et al.]. Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods. Microbial genomics. 2021 7(10). PMID: 34596508. PMCID: PMC8627206.
• Udaondo Z, Sittikankaew K, Uengwetwanit T, [et al., including Nookaew I]. Comparative Analysis of PacBio and Oxford Nanopore Sequencing Technologies for Transcriptomic Landscape Identification of Penaeus monodon. Life (Basel, Switzerland). 2021 11(8). PMID: 34440606. PMCID: PMC8399832.
• Likhitweerawong N, Thonusin C, Boonchooduang N, [et al., including Nookaew I]. Profiles of urine and blood metabolomics in autism spectrum disorders. Metabolic brain disease. 2021. PMID: 34338974. PMCID: PMC8502415.
• Palmieri M, Almeida M, Nookaew I, [et al.]. Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging cell. 2021 20(8):e13442. PMID: 34278710. PMCID: PMC8373359.
• Chopra D, Li C, Painter JT, [et al., including Nookaew I]. Characteristics and Network Influence of Providers Involved in the Treatment of Patients With Chronic Back, Neck or Joint Pain in Arkansas. The journal of pain. 2021. PMID: 34174385.
• Rodionov DA, Rodionova IA, Rodionov VA, [et al., including Nookaew I]. Transcriptional Regulation of Plant Biomass Degradation and Carbohydrate Utilization Genes in the Extreme Thermophile Caldicellulosiruptor bescii. mSystems. 2021:e0134520. PMID: 34060910. PMCID: PMC8579813.
• Kunadirek P, Ariyachet C, Sriphoosanaphan S, [et al., including Nookaew I]. Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. Scientific reports. 2021 11(1):11201. PMID: 34045534. PMCID: PMC8159962.
• Kunadirek P, Chuaypen N, Jenjaroenpun P, [et al., including Nookaew I]. Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand. Cancers. 2021 13(9). PMID: 34066484. PMCID: PMC8125351.
• Gatto F, Volpi N, Nilsson H, [et al., including Nookaew I]. Glycosaminoglycan profiling in patients' plasma and urine predicts the occurrence of metastatic clear cell renal cell carcinoma. Cell reports. 2021 34(9):108795. PMID: 33657373.
• Chuaypen N, Jinato T, Avihingsanon A, [et al., including Nookaew I]. Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection. The Journal of infectious diseases. 2021. PMID: 33598686. PMCID: PMC8557699.
• Uengwetwanit T, Pootakham W, Nookaew I, [et al.]. A chromosome-level assembly of the black tiger shrimp (Penaeus monodon) genome facilitates the identification of growth-associated genes. Molecular ecology resources. 2021. PMID: 33586292. PMCID: PMC8197738.
• Yongkiettrakul S, Wongsurawat T, Jenjaroenpun P, [et al., including Nookaew I]. Genome sequences of antibiotic-resistant Streptococcus suis strains isolated from human patients and diseased and asymptomatic pigs in Thailand. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2021 87:104674. PMID: 33316429. PMCID: PMC8561417.
• Taylor MK, Williams EP, Wongsurawat T, [et al., including Nookaew I]. Corrigendum: Amplicon-Based, Next-Generation Sequencing Approaches to Characterize Single Nucleotide Polymorphisms of Orthohantavirus Species. Frontiers in cellular and infection microbiology. 2021 11:804914. PMID: 35141171. PMCID: PMC8819723.
• Jenjaroenpun P, Wanchai V, Ono-Moore KD, [et al., including Nookaew I]. Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing. Microbiology resource announcements. 2020 10(1). PMID: 33334896. PMCID: PMC8407695.
• Rabe H, Lundell AC, Sjöberg F, [et al., including Nookaew I]. Neonatal gut colonization by Bifidobacterium is associated with higher childhood cytokine responses. Gut microbes. 2020 12(1):1-14. PMID: 33274676. PMCID: PMC7747801.
• Sjöberg F, Nookaew I, Yazdanshenas S, [et al.]. Are all faecal bacteria detected with equal efficiency? A study using next-generation sequencing and quantitative culture of infants' faecal samples. Journal of microbiological methods. 2020 177:106018. PMID: 32795633.
• Svahn SL, Pattanaik B, Grahnemo L, [et al., including Nookaew I]. Spleen proteomics data from high fat diet fed mice. Data in brief. 2020 32:106110. PMID: 32904176. PMCID: PMC7451803.
• Tepaamorndech S, Nookaew I, Higdon SM, [et al.]. Metagenomics in bioflocs and their effects on gut microbiome and immune responses in Pacific white shrimp. Fish & shellfish immunology. 2020 106:733-741. PMID: 32858186.
• Nookaew I, Jenjaroenpun P, Du H, [et al.]. Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing. Chemical research in toxicology. 2020. PMID: 32799528. PMCID: PMC7752846.
• Jenjaroenpun P, Wongsurawat T, Wadley TD, [et al., including Nookaew I]. Decoding the epitranscriptional landscape from native RNA sequences. Nucleic acids research. 2020. PMID: 32710622. PMCID: PMC7826254.
• Kim HN, Ponte F, Nookaew I, [et al.]. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Scientific reports. 2020 10(1):11933. PMID: 32686739. PMCID: PMC7371870.
• Wongsurawat T, Gupta A, Jenjaroenpun P, [et al., including Nookaew I]. Author Correction: R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Scientific reports. 2020 10(1):12173. PMID: 32678142. PMCID: PMC7368006.
• Chokesajjawatee N, Santiyanont P, Chantarasakha K, [et al., including Nookaew I]. Safety Assessment of a Nham Starter Culture Lactobacillus plantarum BCC9546 via Whole-genome Analysis. Scientific reports. 2020 10(1):10241. PMID: 32581273. PMCID: PMC7314741.
• Wongsurawat T, Jenjaroenpun P, De Loose A, [et al., including Nookaew I]. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta neuropathologica communications. 2020 8(1):87. PMID: 32563269. PMCID: PMC7305623.
• Kandel S, Sripiboon S, Jenjaroenpun P, [et al., including Nookaew I]. 16S rRNA Gene Amplicon Profiling of Baby and Adult Captive Elephants in Thailand. Microbiology resource announcements. 2020 9(24). PMID: 32527771. PMCID: PMC7291096.
• Vorapreeda T, Thammarongtham C, Palasak T, [et al., including Nookaew I]. Systematic genome analysis of a novel arachidonic acid-producing strain uncovered unique metabolic traits in the production of acetyl-CoA-derived products in Mortierellale fungi. Gene. 2020 741:144559. PMID: 32169630.
• Wongsurawat T, Gupta A, Jenjaroenpun P, [et al., including Nookaew I]. R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Scientific reports. 2020 10(1):6389. PMID: 32286400. PMCID: PMC7156643.
• Lieven C, Beber ME, Olivier BG, [et al., including Nookaew I]. Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing. Nature biotechnology. 2020 38(4):504. PMID: 32265554. PMCID: PMC7138757.
• Sittikankaew K, Pootakham W, Sonthirod C, [et al., including Nookaew I]. Author Correction: Transcriptome analyses reveal the synergistic effects of feeding and eyestalk ablation on ovarian maturation in black tiger shrimp. Scientific reports. 2020 10(1):5481. PMID: 32198472. PMCID: PMC7083951.
• Lieven C, Beber ME, Olivier BG, [et al., including Nookaew I]. MEMOTE for standardized genome-scale metabolic model testing. Nature biotechnology. 2020 38(3):272-276. PMID: 32123384. PMCID: PMC7082222.
• Sittikankaew K, Pootakham W, Sonthirod C, [et al., including Nookaew I]. Transcriptome analyses reveal the synergistic effects of feeding and eyestalk ablation on ovarian maturation in black tiger shrimp. Scientific reports. 2020 10(1):3239. PMID: 32094422. PMCID: PMC7040003.
• Jenjaroenpun P, Wongsurawat T, Udaondo Z, [et al., including Nookaew I]. Complete Genome Sequences of Four Isolates of Vancomycin-Resistant Enterococcus faecium with the vanA Gene and Two Daptomycin Resistance Mutations, Obtained from Two Inpatients with Prolonged Bacteremia. Microbiology resource announcements. 2020 9(6). PMID: 32029568. PMCID: PMC7005116.
• Khoomrung S, Nookaew I, Sen P, [et al.]. Metabolic Profiling and Compound-Class Identification Reveal Alterations in Serum Triglyceride Levels in Mice Immunized with Human Vaccine Adjuvant Alum. Journal of proteome research. 2020 19(1):269-278. PMID: 31625748. PMCID: PMC7735194.
• Cheawchanlertfa P, Sutheeworapong S, Jenjaroenpun P, [et al., including Nookaew I]. Clostridium manihotivorum sp. nov., a novel mesophilic anaerobic bacterium that produces cassava pulp-degrading enzymes. PeerJ. 2020 8:e10343. PMID: 33240652. PMCID: PMC7676355.
• Limjiasahapong S, Kaewnarin K, Jariyasopit N, [et al., including Nookaew I]. UPLC-ESI-MRM/MS for Absolute Quantification and MS/MS Structural Elucidation of Six Specialized Pyranonaphthoquinone Metabolites From Ventilago harmandiana. Frontiers in plant science. 2020 11:602993. PMID: 33505413. PMCID: PMC7830255.
• Wanchai V, Nookaew I, Ussery DW. ProdMX: Rapid query and analysis of protein functional domain based on compressed sparse matrices. Computational and structural biotechnology journal. 2020 18:3890-3896. PMID: 33335686. PMCID: PMC7719867.
• Skinner CM, Nookaew I, Ewing LE, [et al.]. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. Journal of dietary supplements. 2020 17(5):543-560. PMID: 32400224. PMCID: PMC7470626.
• Angthong P, Uengwetwanit T, Pootakham W, [et al., including Nookaew I]. Optimization of high molecular weight DNA extraction methods in shrimp for a long-read sequencing platform. PeerJ. 2020 8:e10340. PMID: 33240651. PMCID: PMC7668203.
• Taylor MK, Williams EP, Wongsurawat T, [et al., including Nookaew I]. Amplicon-Based, Next-Generation Sequencing Approaches to Characterize Single Nucleotide Polymorphisms of Orthohantavirus Species. Frontiers in cellular and infection microbiology. 2020 10:565591. PMID: 33163416. PMCID: PMC7591466.
• Pornputtapong N, Acheampong DA, Patumcharoenpol P, [et al., including Nookaew I]. KITSUNE: A Tool for Identifying Empirically Optimal K-mer Length for Alignment-Free Phylogenomic Analysis. Frontiers in bioengineering and biotechnology. 2020 8:556413. PMID: 33072720. PMCID: PMC7538862.
• Waldrip ZJ, Jenjaroenpun P, DeYoung O, [et al., including Nookaew I]. Genome-wide Cas9 binding specificity in Saccharomyces cerevisiae. PeerJ. 2020 8:e9442. PMID: 32821531. PMCID: PMC7395602.
• Woo CC, Liu W, Lin XY, [et al., including Nookaew I]. The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International journal of molecular sciences. 2019 21(1). PMID: 31861407. PMCID: PMC6982107.