Kevin D Raney, PhD
Full Member
Research Program:
Cancer Biology
Faculty Rank:
Professor
Campus:
University of Arkansas for Medical Sciences
College:
College of Medicine
Department:
Biochemistry & Molecular Biology
|
Cancer Research Interest
- Disease Site Focus: No Specific Disease Site
- Research Focus Area: Carcinogenesis
- Type of Research: Basic
Contact Information
- Email Address: RANEYKEVIND@UAMS.EDU
- Profiles Research Networking Software: View Profile
Active Grants
- NIH/Nat. Inst. of Allergy & Infectious Diseases – U19AI171954“Midwest AViDD Center”Principal Investigator05/16/22 – 04/30/27
- NIH/Nat. Inst. of Allergy & Infectious Diseases – R01AI161841“Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron”Principal Investigator05/01/22 – 02/28/25
Publications
- Chib S, Griffin WC, Gao J, [et al., including Raney KD]. Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA. Biochemistry. 2023. PMID: 37948114. PMCID: PMC10841737.
- Belachew B, Gao J, Byrd AK, Raney KD. Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures. The Journal of biological chemistry. 2022 298(11):102486. PMID: 36108740. PMCID: PMC9582721.
- Delgado M, Rainwater RR, Heflin B, [et al., including Raney KD]. Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways. The Journal of biological chemistry. 2022 298(6):101939. PMID: 35436470. PMCID: PMC9123221.
- Ozaslan D, Byrd AK, Belachew B, Raney KD. Alignment of helicases on single-stranded DNA increases activity. Methods in enzymology. 2022 672:29-54. PMID: 35934480. PMCID: PMC9421817.
- Byrd AK, Malone EG, Hazeslip L, [et al., including Raney KD]. A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA. Protein science : a publication of the Protein Society. 2021. PMID: 34761452. PMCID: PMC8819844.
- Gao J, Gao Z, Putnam AA, [et al., including Raney KD]. G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p. Chemical communications (Cambridge, England). 2021. PMID: 34232232. PMCID: PMC8315639.
- Marecki JC, Byrd AK, Raney KD. Identifying RNA Helicase Inhibitors Using Duplex Unwinding Assays. Methods in molecular biology (Clifton, N.J.). 2021 2209:53-72. PMID: 33201462. PMCID: PMC8862664.
- Marecki JC, Belachew B, Gao J, Raney KD. RNA helicases required for viral propagation in humans. The Enzymes. 2021 50:335-367. PMID: 34861942. PMCID: PMC8562938.
- Edwards AD, Marecki JC, Byrd AK, [et al., including Raney KD]. G-Quadruplex loops regulate PARP-1 enzymatic activation. Nucleic acids research. 2020. PMID: 33313902. PMCID: PMC7797039.
- Butler TJ, Estep KN, Sommers JA, [et al., including Raney KD]. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro. Human molecular genetics. 2020 29(8):1292-1309. PMID: 32191790. PMCID: PMC7254849.
- Singh A, Pandey M, Nandakumar D, [et al., including Raney KD]. Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles. The EMBO journal. 2020 39(6):e103367. PMID: 32037587. PMCID: PMC7073461.
- Waldrip ZJ, Jenjaroenpun P, DeYoung O, [et al., including Raney KD]. Genome-wide Cas9 binding specificity in Saccharomyces cerevisiae. PeerJ. 2020 8:e9442. PMID: 32821531. PMCID: PMC7395602.
- Su N, Byrd AK, Bharath SR, [et al., including Raney KD]. Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases. Nature communications. 2019 10(1):5375. PMID: 31772234. PMCID: PMC6879534.
- Lu C, Le S, Chen J, [et al., including Raney KD]. Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase. Nucleic acids research. 2019 47(14):7494-7501. PMID: 31216020. PMCID: PMC6698741.
- Gao J, Byrd AK, Zybailov BL, [et al., including Raney KD]. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chemical communications (Cambridge, England). 2019 55(31):4467-4470. PMID: 30855040. PMCID: PMC6459694.