Kevin D Raney, PhD

Research Program: Cancer Biology Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Department Chairs

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Carcinogenesis
• Type of Research: Basic

Contact Information

• Email Address: RANEYKEVIND@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIGMS – 1P20GM152281
  “Biomolecular Interactions Core”
  Principal Investigator
  3/5/2024 – 12/31/2028
• NIH/Nat. Inst. of Allergy & Infectious Diseases – U19AI171954
  “Midwest AViDD Center”
  Principal Investigator
  5/16/2022 – 4/30/2027
• NIH/Nat. Inst. of Allergy & Infectious Diseases – R01AI161841
  “Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron”
  Principal Investigator
  5/1/2022 – 2/28/2025

Recent Publications

• Hong Z, Byrd AK, Gao J, [et al., including Raney KD]. Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge. Nature communications. 2024 15(1):6104. PMID: 39030241. PMCID: PMC11275212.
• Gao J, Proffitt DR, Marecki JC, [et al., including Raney KD]. Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth. Nucleic acids research. 2024. PMID: 38752483. PMCID: PMC11194084.
• Chib S, Griffin WC, Gao J, [et al., including Raney KD]. Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA. Biochemistry. 2023. PMID: 37948114. PMCID: PMC10841737.
• Belachew B, Gao J, Byrd AK, Raney KD. Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures. The Journal of biological chemistry. 2022 298(11):102486. PMID: 36108740. PMCID: PMC9582721.
• Delgado M, Rainwater RR, Heflin B, [et al., including Raney KD]. Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways. The Journal of biological chemistry. 2022 298(6):101939. PMID: 35436470. PMCID: PMC9123221.
• Ozaslan D, Byrd AK, Belachew B, Raney KD. Alignment of helicases on single-stranded DNA increases activity. Methods in enzymology. 2022 672:29-54. PMID: 35934480. PMCID: PMC9421817.
• Byrd AK, Malone EG, Hazeslip L, [et al., including Raney KD]. A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA. Protein science : a publication of the Protein Society. 2021. PMID: 34761452. PMCID: PMC8819844.
• Gao J, Gao Z, Putnam AA, [et al., including Raney KD]. G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p. Chemical communications (Cambridge, England). 2021. PMID: 34232232. PMCID: PMC8315639.
• Marecki JC, Byrd AK, Raney KD. Identifying RNA Helicase Inhibitors Using Duplex Unwinding Assays. Methods in molecular biology (Clifton, N.J.). 2021 2209:53-72. PMID: 33201462. PMCID: PMC8862664.
• Marecki JC, Belachew B, Gao J, Raney KD. RNA helicases required for viral propagation in humans. The Enzymes. 2021 50:335-367. PMID: 34861942. PMCID: PMC8562938.
• Edwards AD, Marecki JC, Byrd AK, [et al., including Raney KD]. G-Quadruplex loops regulate PARP-1 enzymatic activation. Nucleic acids research. 2020. PMID: 33313902. PMCID: PMC7797039.
• Butler TJ, Estep KN, Sommers JA, [et al., including Raney KD]. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro. Human molecular genetics. 2020 29(8):1292-1309. PMID: 32191790. PMCID: PMC7254849.
• Singh A, Pandey M, Nandakumar D, [et al., including Raney KD]. Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles. The EMBO journal. 2020 39(6):e103367. PMID: 32037587. PMCID: PMC7073461.
• Waldrip ZJ, Jenjaroenpun P, DeYoung O, [et al., including Raney KD]. Genome-wide Cas9 binding specificity in Saccharomyces cerevisiae. PeerJ. 2020 8:e9442. PMID: 32821531. PMCID: PMC7395602.