Research Focus Area:
Treatment, Carcinogenesis, Diagnosis/ Prognosis
Type of Research:
Research Interest Statement:
My research interests relate to inhibiting cancer growth and metastasis by defining and targeting the pathways used by macrophages to recognize and respond to factors in the tumor microenvironment.
“Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients”
05/01/19 – 04/30/24
NIH/Nat. Heart, Lung & Blood Institute – 1R01HL146713
“T cell homing to the kidney contributes to salt retention and blood pressure regulation”
04/01/19 – 03/31/24
UAMS Executive Breast Committee – ABCRP FY19
“Role of SR-A Binding to Tumor-Associated Glycans in Breast Cancer”
02/01/19 – 08/31/22
Chen J, Dai L, Kendrick S, [et al., including Post SR]. The anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesviruses Reactivation through Regulation of Intracellular Signaling Pathways. Antimicrobial agents and chemotherapy. 2022:aac0239521. PMID: 35041508.
Dai L, Lu YC, Chen J, [et al., including Post SR]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
Chen J, Dai L, Barrett L, [et al., including Post SR]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. Communications biology. 2021 4(1):682. PMID: 34083759. PMCID: PMC8175744.
Del Valle L, Dai L, Lin HY, [et al., including Post SR]. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine. 2021. PMID: 33539648.
Chen J, Dai L, Barrett L, [et al., including Post SR]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. bioRxiv : the preprint server for biology. 2020. PMID: 33024968. PMCID: PMC7536871.
Dai L, Jung BG, Chen J, [et al., including Post SR]. The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938.
Chen J, Goyal N, Dai L, [et al., including Post S]. Developing new ceramide analogs and identifying novel sphingolipid controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949.
Murray GP, Post SR, Post GR. ABO blood group is a determinant of von Willebrand factor protein levels in human pulmonary endothelial cells. Journal of clinical pathology. 2020 73(6):347-349. PMID: 31662441. PMCID: PMC7279561.
Dai L, Forrest J, Barrett L, [et al., including Post SR]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999.
Dai L, Forrest J, Qiao J, [et al., including Post SR]. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. The Journal of infectious diseases. 2020 221(8):1331-1341. PMID: 31111897.
Chen J, Forrest J, post s, [et al.]. Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. Viruses. 2019 11(12). PMID: 31888174. PMCID: PMC6950054.
Chen J, Dai L, Goldstein A, [et al., including Post SR]. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS pathogens. 2019 15(12):e1008156. PMID: 31790497. PMCID: PMC6907871.
Chen J, Del Valle L, Lin HY, [et al., including Post SR]. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 536:16-19. PMID: 31394407. PMCID: PMC6733645.
Madan E, Pelham CJ, Nagane M, [et al., including Post SR]. Flower isoforms promote competitive growth in cancer. Nature. 2019 572(7768):260-264. PMID: 31341286.
Asfari A, post s, Dent JA, [et al.]. Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis. Thrombosis and haemostasis. 2019 119(3):431-438. PMID: 30597490.
Chen J, Forrest J, post s, [et al.]. Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies. Oncogenesis. 2019 8(1):6. PMID: 30643113. PMCID: PMC6331641.
Post GR, Yuan Y, Holthoff ER, [et al., including Post SR]. Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment. PloS one. 2019 14(11):e0224621. PMID: 31714922. PMCID: PMC6850552.
Post SR, Kelly T, Post GR, [et al.]. Development of an unbiased, semi-automated approach for classifying plasma cell immunophenotype following multicolor flow cytometry of bone marrow aspirates. Cytometry. Part B, Clinical cytometry. 2018 94(5):602-610. PMID: 29573142. PMCID: PMC6150794.
Xu W, Forrest J, post s, [et al.]. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific reports. 2018 8(1):12863. PMID: 30150778. PMCID: PMC6110826.
Post GR, Kelly T, Guillory E, [et al., including Post SR]. Effect of Serum Immunoglobulins on Routine Coagulation Tests: A Comparison of Coagulation Analyzers using Mechanical and Optical Clot Detection. Annals of clinical and laboratory science. 2017 47(6):744-746. PMID: 29263049.
PrabhuDas MR, Baldwin CL, Bollyky PL, [et al., including Post SR]. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. Journal of immunology (Baltimore, Md. : 1950). 2017 198(10):3775-3789. PMID: 28483986. PMCID: PMC5671342.
Holthoff ER, Byrum SD, Mackintosh SG, [et al., including Post SR]. Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. Clinical proteomics. 2017 14:40. PMID: 29225558. PMCID: PMC5717999.
Holthoff ER, Spencer H, Kelly T, [et al., including Post SR]. Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition. Human pathology. 2016 56:22-30. PMID: 27327194. PMCID: PMC5021565.
Post GR, Bell RC, Rjoop A, [et al., including Post SR]. Diagnostic Utility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies. Annals of clinical and laboratory science. 2016 46(5):474-9. PMID: 27650613.
Mazur A, Holthoff E, Vadali S, [et al., including Post SR]. Cleavage of Type I Collagen by Fibroblast Activation Protein-? Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PloS one. 2016 11(3):e0150287. PMID: 26934296. PMCID: PMC4774960.
Jeffus SK, Gehlot A, Holthoff E, [et al., including Post SR]. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. The American journal of surgical pathology. 2015 39(9):1226-33. PMID: 26274029. PMCID: PMC4538995.
Holthoff ER, Jeffus SK, Gehlot A, [et al., including Post SR]. Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. The American journal of surgical pathology. 2015 39(8):1070-4. PMID: 25786085. PMCID: PMC4503485.