Charles A O'Brien, PhD

Full Member

Research Program:

Cancer Biology

Faculty Rank:

Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Internal Med Endo

Cancer Research Interest

Disease Site Focus: Musculoskeletal
Research Focus Area: Carcinogenesis
Type of Research: Basic
Research Interest Statement: I am a skeletal biologist and my research focuses on the mechanisms that control bone remodeling, a process which is disrupted by cancers such as myeloma or breast cancer metastasis.

NIH/Nat. Inst. of General Medical Sciences – 2P20GM125503
“Center for Musculoskeletal Disease Research (CMDR)”
Principal Investigator
4/1/2023 – 1/31/2028
NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases – 2R01AR049794
“Osteocyte Control of Bone Remodeling”
Principal Investigator
4/1/2022 – 3/31/2027
NIH/Nat. Inst. on Aging – 1R01AG068449
“Different consequences of cellular aging in cortical versus cancellous bone”
Principal Investigator
4/1/2021 – 12/31/2025

Palmieri M, Joseph TE, O'Brien CA, [et al.]. Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass. PloS one. 2022 17(3):e0265893. PMID: 35349600. PMCID: PMC8963559.
Sherman AC, Simonton-Atchley S, O'Brien CE, [et al.]. Associations Between Religious/Spiritual Coping and Depression Among Adults with Cystic Fibrosis: A 12-Month Longitudinal Study. Journal of religion and health. 2021. PMID: 33575892.
Kim HN, Xiong J, MacLeod RS, [et al., including O'Brien CA]. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI insight. 2020 5(19). PMID: 32870816. PMCID: PMC7566701.
Plotkin M, O'Brien CA, Goellner J, [et al.]. A Uromodulin Mutation Drives Autoimmunity and Kidney Mononuclear Phagocyte Endoplasmic Reticulum Stress. The American journal of pathology. 2020. PMID: 32926855. PMCID: PMC7722528.
Cawley KM, Bustamante-Gomez NC, Guha AG, [et al., including O'Brien CA]. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell reports. 2020 32(10):108052. PMID: 32905775. PMCID: PMC7493998.
Sherman AC, Simonton-Atchley S, O'Brien CE, [et al.]. Longitudinal associations between gratitude and depression 1 year later among adult cystic fibrosis patients. Journal of behavioral medicine. 2020 43(4):596-604. PMID: 31254218.