Angus MacNicol, PhD

Research Program: Cancer Biology Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Neuro & Devel Sci Faculty

Contact Information

• Email Address: ANGUS@UAMS.EDU
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Active Grants

• NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases – 1R01DK139476
  “Molecular mechanisms of pituitary plasticity”
  Principal Investigator
  9/18/2024 – 5/31/2029
• NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases – 1R01DK127723
  “The Impact of Obesity on Somatotrope Function”
  Principal Investigator
  7/1/2021 – 6/30/2025
• NIH/Nat. Inst. of Child Health & Human Development – 1R01HD093461
  “Control of pituitary cell plasticity through regulated mRNA translation - Continuation”
  Principal Investigator
  9/1/2018 – 6/30/2025

Recent Publications

• Banik J, Moreira ARS, Lim J, [et al., including MacNicol AM]. The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Scientific reports. 2024 14(1):5918. PMID: 38467682. PMCID: PMC10928108.
• Miles TK, Odle AK, Byrum SD, [et al., including MacNicol AM]. Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism. Endocrinology. 2023 165(2). PMID: 38103263. PMCID: PMC10771268.
• Moreira ARS, Lim J, Urbaniak A, [et al., including MacNicol AM]. Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle. Endocrinology. 2023 164(9). PMID: 37477898. PMCID: PMC10402870.
• Miles TK, Allensworth-James ML, Odle AK, [et al., including MacNicol AM]. Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain. Frontiers in endocrinology. 2023 14:1332959. PMID: 38720938. PMCID: PMC11077627.
• Urbaniak A, Reed MR, Heflin B, [et al., including MacNicol AM]. Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 153:113440. PMID: 36076555. PMCID: PMC9472755.
• Urbaniak A, Reed MR, Fil D, [et al., including MacNicol AM]. Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 141:111815. PMID: 34130123. PMCID: PMC8429223.
• Ruf-Zamojski F, MacNicol A, Zhang Z, [et al.]. Single nucleus multi-omics regulatory landscape of the murine pituitary. Nature communications. 2021 12(1):2677. PMID: 33976139. PMCID: PMC8113460.
• Odle AK, MacNicol MC, Childs GV, MacNicol AM. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. International journal of molecular sciences. 2021 22(7). PMID: 33805020. PMCID: PMC8038027.
• Allensworth-James M, Banik J, Odle A, [et al., including MacNicol AM]. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi. Endocrinology. 2021 162(3). PMID: 33570120.
• Allensworth-James M, Banik J, Odle A, [et al., including MacNicol AM]. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi. Endocrinology. 2021 162(3). PMID: 33373440. PMCID: PMC7814296.
• Miles TK, Silva Moreira AR, Allensworth-James ML, [et al., including MacNicol AM]. Sex differences in somatotrope response to fasting: biphasic responses in male mice. The Journal of endocrinology. 2020 247(3):213-224. PMID: 33112825. PMCID: PMC7673470.
• Childs GV, Odle AK, MacNicol MC, MacNicol AM. The Importance of Leptin to Reproduction. Endocrinology. 2020. PMID: 33165520. PMCID: PMC7749705.
• Allensworth-James ML, Odle AK, Lim J, [et al., including MacNicol AM]. Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators. Journal of neuroendocrinology. 2020:e12883. PMID: 32657474. PMCID: PMC8086172.
• Childs GV, MacNicol AM, MacNicol MC. Molecular Mechanisms of Pituitary Cell Plasticity. Frontiers in endocrinology. 2020 11:656. PMID: 33013715. PMCID: PMC7511515.