Research Focus Area:
Health Disparities, Treatment, Carcinogenesis, Diagnosis/ Prognosis
Type of Research:
Research Interest Statement:
I study the tumor microenvironment and the role of normal host cells such as fibroblasts and macrophages in promoting outgrowth and metastasis of tumors. I am focused primarily on breast cancer and use both the Mouse Mammary Tumor Virus-Polyma Middle T model as well as clinical samples.
NIH/Nat. Inst. of General Medical Sciences – 2P20GM103429
“Partnerships for Biomedical Research in Arkansas”
05/01/20 – 04/30/25
Zhang H, Ramsey A, Xiao Y, [et al., including Kelly T]. Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion. Molecular and cellular biology. 2020 40(4). PMID: 31791978. PMCID: PMC6996279.
Wu H, Hasan R, Zhang H, [et al., including Kelly T]. Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells. Scientific reports. 2019 9(1):4925. PMID: 30894654. PMCID: PMC6426867.
Post SR, Kelly T, Post GR, [et al.]. Development of an unbiased, semi-automated approach for classifying plasma cell immunophenotype following multicolor flow cytometry of bone marrow aspirates. Cytometry. Part B, Clinical cytometry. 2018 94(5):602-610. PMID: 29573142. PMCID: PMC6150794.
Post GR, Kelly T, Guillory E, [et al.]. Effect of Serum Immunoglobulins on Routine Coagulation Tests: A Comparison of Coagulation Analyzers using Mechanical and Optical Clot Detection. Annals of clinical and laboratory science. 2017 47(6):744-746. PMID: 29263049.
Holthoff ER, Byrum SD, Mackintosh SG, [et al., including Kelly T]. Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. Clinical proteomics. 2017 14:40. PMID: 29225558. PMCID: PMC5717999.
Holthoff ER, Spencer H, Kelly T, [et al.]. Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition. Human pathology. 2016 56:22-30. PMID: 27327194. PMCID: PMC5021565.
Mazur A, Holthoff E, Vadali S, [et al., including Kelly T]. Cleavage of Type I Collagen by Fibroblast Activation Protein-? Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PloS one. 2016 11(3):e0150287. PMID: 26934296. PMCID: PMC4774960.
Jeffus SK, Gehlot A, Holthoff E, [et al., including Kelly T]. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. The American journal of surgical pathology. 2015 39(9):1226-33. PMID: 26274029. PMCID: PMC4538995.
Holthoff ER, Jeffus SK, Gehlot A, [et al., including Kelly T]. Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. The American journal of surgical pathology. 2015 39(8):1070-4. PMID: 25786085. PMCID: PMC4503485.