Brian Spencer Koss, PhD
Full Member
Research Program:
Cancer Biology
Faculty Rank:
Assistant Professor
Campus:
University of Arkansas for Medical Sciences
College:
College of Medicine
Department:
Biochemistry & Molecular Biology
|
Cancer Research Interest
- Research Interest Statement: I am interested in exploring the molecular mechanisms T cells utilize to sense and adapt to environmental stress, focusing on the immune control of cancer. My work utilizes specialized proteomic approaches to established immune monitoring strategies and to inform the development of cellular therapies.
Contact Information
- Email Address: BSKOSS@UAMS.EDU
- Profiles Research Networking Software: View Profile
Active Grants
- NIH/Office of the Director – 1DP5OD031863“Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment ”Principal Investigator09/01/21 – 08/31/26
Publications
- Frett B, Stephens KE, Koss B, [et al.]. Enhancer-activated RET confers protection against oxidative stress to KMT2A-rearranged acute myeloid leukemia. Cancer science. 2024. PMID: 38226414. PMCID: PMC10920984.
- Morehead LC, Koss B, Fil D, [et al.]. Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma. Molecular immunology. 2023 163:188-195. PMID: 37837954. PMCID: PMC10792541.
- Azevedo-Pouly AC, Appell LE, Burdine L, [et al., including Koss B]. Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4(+) helper and CD8(+) effector T cells. Immunology and cell biology. 2023. PMID: 37149747. PMCID: PMC10527493.
- Guzman G, Reed MR, Bielamowicz K, [et al., including Koss B]. CAR-T Therapies in Solid Tumors: Opportunities and Challenges. Current oncology reports. 2023. PMID: 36853475. PMCID: PMC10110629.
- Choudhury S, Heflin B, Taylor E, [et al., including Koss B]. CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells. Cells. 2023 12(5). PMID: 36899866. PMCID: PMC10000373.
- Koss B, Boerma M, Shields BD, [et al.]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
- Trentzsch M, Nyamugenda E, Miles TK, [et al., including Koss B]. Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Cell death discovery. 2020 6:8. PMID: 32123584. PMCID: PMC7028721.
- Taylor EM, Koss B, Davis LE, Tackett AJ. Histone Modifications as Biomarkers for Immunotherapy. Methods in molecular biology (Clifton, N.J.). 2020 2055:213-228. PMID: 31502154.
- Ren Z, Ahn JH, Liu H, [et al., including Koss B]. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019 134(14):1176-1189. PMID: 31383640. PMCID: PMC6776795.
- Chiang TC, Koss B, Su L, [et al.]. Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth. Medicines (Basel, Switzerland). 2019 6(3). PMID: 31252639. PMCID: PMC6789461.